Publicaciones en colaboración con investigadores/as de Icahn School of Medicine at Mount Sinai (41)

2024

  1. Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis

    Nature Structural and Molecular Biology, Vol. 31, Núm. 9, pp. 1394-1403

  2. SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

    Cell Reports, Vol. 43, Núm. 3

  3. The molecular architecture of the nuclear basket

    Cell

2022

  1. Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch

    Nature Communications, Vol. 13, Núm. 1

2021

  1. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Autophagy, Vol. 17, Núm. 1, pp. 1-382

2020

  1. Presenilin1 familial Alzheimer disease mutants inactivate EFNB1-and BDNF-dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of N-methyl-d-Aspartate receptor

    Brain Communications, Vol. 2, Núm. 2

  2. Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin

    Nature Communications, Vol. 11, Núm. 1

  3. Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis

    Nature Structural and Molecular Biology, Vol. 27, Núm. 10, pp. 913-924

  4. Substrate interaction inhibits γ-secretase production of amyloid-β peptides

    Chemical Communications, Vol. 56, Núm. 17, pp. 2578-2581

2019

  1. Vitamin B 12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection

    Cell Research, Vol. 29, Núm. 4, pp. 313-329

  2. CD46 facilitates entry and dissemination of human cytomegalovirus

    Nature Communications, Vol. 10, Núm. 1

  3. Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme

    Nature Structural and Molecular Biology, Vol. 26, Núm. 10, pp. 955-962

  4. Somatic mutations and cell identity linked by Genotyping of Transcriptomes

    Nature, Vol. 571, Núm. 7765, pp. 355-360

2018

  1. Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloid Precursor Protein

    Scientific Reports, Vol. 8, Núm. 1

  2. Design and validation of an open-source modular Microplate Photoirradiation System for high-Throughput photobiology experiments

    PLoS ONE, Vol. 13, Núm. 10

  3. Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease

    Science Translational Medicine, Vol. 10, Núm. 423

  4. Histone Native Chromatin Immunoprecipitation

    Methods in Molecular Biology (Humana Press Inc.), pp. 77-104

  5. Unwinding of the Substrate Transmembrane Helix in Intramembrane Proteolysis

    Biophysical Journal, Vol. 114, Núm. 7, pp. 1579-1589

2017

  1. A New Method to Determine the Transmembrane Conformation of Substrates in Intramembrane Proteolysis by Deep-UV Resonance Raman Spectroscopy

    Methods in Enzymology (Academic Press Inc.), pp. 207-228

2016

  1. Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Núm. 30, pp. E4357-E4366