Tamas
Horvath
Senior researcher
Luis
Varela Fernández
Principal Investigator
Publicaciones en las que colabora con Luis Varela Fernández (31)
2024
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Ghrelin
Trends in Endocrinology and Metabolism
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Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation
Nature Communications, Vol. 15, Núm. 1
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microRNA-33 controls hunger signaling in hypothalamic AgRP neurons
Nature Communications, Vol. 15, Núm. 1
2023
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CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice
Nature Communications, Vol. 14, Núm. 1
2022
2021
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Astrocytic lipid metabolism determines susceptibility to diet-induced obesity
Science Advances, Vol. 7, Núm. 50
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Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1
Nature Communications, Vol. 12, Núm. 1
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Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice
Journal of Clinical Investigation, Vol. 131, Núm. 17
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Hunger-promoting AgRP neurons trigger an astrocyte-mediated feed-forward autoactivation loop in mice
Journal of Clinical Investigation, Vol. 131, Núm. 10
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Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis
Cell Metabolism, Vol. 33, Núm. 9, pp. 1820-1835.e9
2020
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GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function
Cell Metabolism, Vol. 31, Núm. 6, pp. 1189-1205.e13
2019
2018
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Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis
JCI insight, Vol. 3, Núm. 6
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Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis
Molecular Metabolism, Vol. 11, pp. 59-69
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Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity
Cell Reports, Vol. 24, Núm. 5, pp. 1085-1092.e6
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Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity
Cell Reports, Vol. 25, Núm. 2, pp. 383-397.e10
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Neuronal Cilia: Another Player in the Melanocortin System
Trends in Molecular Medicine
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The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development
Cell, Vol. 175, Núm. 4, pp. 1088-1104.e23
2017
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Endothelial HIF-1α enables hypothalamic glucose uptake to drive POMC neurons
Diabetes, Vol. 66, Núm. 6, pp. 1511-1520
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Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control
Cell Metabolism, Vol. 25, Núm. 6, pp. 1390-1399.e6