Publicaciones (49) Publicaciones de Luis Varela Fernández

2024

  1. microRNA-33 controls hunger signaling in hypothalamic AgRP neurons

    Nature Communications, Vol. 15, Núm. 1

2023

  1. CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice

    Nature Communications, Vol. 14, Núm. 1

2022

  1. Oncogenic Pathways in Neurodegenerative Diseases

    International Journal of Molecular Sciences, Vol. 23, Núm. 6

  2. Paraventricular glia drive circuit function to control metabolism

    Cell Metabolism

2021

  1. Astrocytic lipid metabolism determines susceptibility to diet-induced obesity

    Science Advances, Vol. 7, Núm. 50

  2. Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1

    Nature Communications, Vol. 12, Núm. 1

  3. Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice

    Journal of Clinical Investigation, Vol. 131, Núm. 17

  4. Hunger-promoting AgRP neurons trigger an astrocyte-mediated feed-forward autoactivation loop in mice

    Journal of Clinical Investigation, Vol. 131, Núm. 10

  5. Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis

    Cell Metabolism, Vol. 33, Núm. 9, pp. 1820-1835.e9

2020

  1. AMPK-Dependent Mechanisms but Not Hypothalamic Lipid Signaling Mediates GH-Secretory Responses to GHRH and Ghrelin

    Cells, Vol. 9, Núm. 9

  2. Beneficial effects of bariatric surgery-induced by weight loss on the proteome of abdominal subcutaneous adipose tissue

    Journal of Clinical Medicine, Vol. 9, Núm. 1

  3. GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function

    Cell Metabolism, Vol. 31, Núm. 6, pp. 1189-1205.e13

2019

  1. Parallel Paths in PVH Control of Feeding

    Neuron

2018

  1. Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis

    JCI insight, Vol. 3, Núm. 6

  2. Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis

    Molecular Metabolism, Vol. 11, pp. 59-69

  3. Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity

    Cell Reports, Vol. 24, Núm. 5, pp. 1085-1092.e6

  4. Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity

    Cell Reports, Vol. 25, Núm. 2, pp. 383-397.e10

  5. Neuronal Cilia: Another Player in the Melanocortin System

    Trends in Molecular Medicine

  6. The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development

    Cell, Vol. 175, Núm. 4, pp. 1088-1104.e23

2017

  1. Endothelial HIF-1α enables hypothalamic glucose uptake to drive POMC neurons

    Diabetes, Vol. 66, Núm. 6, pp. 1511-1520