Laboratory of Neuropathology of interorganellar contact sites
Oferta científica
- TECHNIQUES: MERLIN, a novel BRET based biosensor for MERCS assessment in different cellular systems (immortalized cells, neuroprogenitors and mature neurones). Proximity-dependent biotin labelling coupled to mass spectrometry (MS) optimized for MERCS characterization. Microscopy: confocal, STED, EM. Cell death assays (caspase activation, inflammation signalling, in vitro reconstitution systems like model membranes or isolated mitochondria, and others).