Structural Biology of Disease Mechanisms Laboratory
Publicaciones (63) Publicaciones en las que ha participado algún/a investigador/a
2024
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Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis
Nature Structural and Molecular Biology, Vol. 31, Núm. 9, pp. 1394-1403
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Purification of functional recombinant human mitochondrial Hsp60
Methods in Enzymology
2023
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Cyclic di-AMP traps proton-coupled K+ transporters of the KUP family in an inward-occluded conformation
Nature Communications, Vol. 14, Núm. 1
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Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane
Nature Communications, Vol. 14, Núm. 1
2022
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Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch
Nature Communications, Vol. 13, Núm. 1
2021
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Conformational plasticity underlies membrane fusion induced by an HIV sequence juxtaposed to the lipid envelope
Scientific Reports, Vol. 11, Núm. 1
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Enzyme Storage and Recycling: Nanoassemblies of α-Amylase and Xylanase Immobilized on Biomimetic Magnetic Nanoparticles
ACS Sustainable Chemistry and Engineering, Vol. 9, Núm. 11, pp. 4054-4063
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Tying up the Loose Ends: A Mathematically Knotted Protein
Frontiers in Chemistry, Vol. 9
2020
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Presenilin1 familial Alzheimer disease mutants inactivate EFNB1-and BDNF-dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of N-methyl-d-Aspartate receptor
Brain Communications, Vol. 2, Núm. 2
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Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin
Nature Communications, Vol. 11, Núm. 1
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Structural basis of proton-coupled potassium transport in the KUP family
Nature Communications, Vol. 11, Núm. 1
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Structural insight into the membrane targeting domain of the Legionella deAMPylase SidD
PLoS Pathogens, Vol. 16, Núm. 8
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Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis
Nature Structural and Molecular Biology, Vol. 27, Núm. 10, pp. 913-924
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Substrate interaction inhibits γ-secretase production of amyloid-β peptides
Chemical Communications, Vol. 56, Núm. 17, pp. 2578-2581
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Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype
Frontiers in Molecular Neuroscience, Vol. 13
2019
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Vitamin B 12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection
Cell Research, Vol. 29, Núm. 4, pp. 313-329
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Biomimetic magnetic nanocarriers drive choline kinase alpha inhibitor inside cancer cells for combined chemo-hyperthermia therapy
Pharmaceutics, Vol. 11, Núm. 8
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CD46 facilitates entry and dissemination of human cytomegalovirus
Nature Communications, Vol. 10, Núm. 1
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Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme
Nature Structural and Molecular Biology, Vol. 26, Núm. 10, pp. 955-962
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Sustained sensing in potassium homeostasis: Cyclic di-AMP controls potassium uptake by KimA at the levels of expression and activity
Journal of Biological Chemistry, Vol. 294, Núm. 24, pp. 9605-9614