Epe luzerako ondorioak loki-lobuluko epilepsia sagu-eredu baten garunean

  1. Garazi Ocerin Amondarain 1
  2. Ilazki Anaut Lusar
  3. Amaia Mimenza Saiz
  4. Leire Lekunberri
  5. Maitane Serrano Murgia
  6. Edgar Soria-Gómez
  7. Inmaculada Gerrikagoitia Marina
  8. Irantzu Rico Barrio
  9. Nagore Puente Bustinza
  10. Jon Egaña Huguet
  11. Izaskun Elezgarai Gabantxo
  12. Pedro Rolando Grandes Moreno
  1. 1 Universidad del País Vasco/Euskal Herriko Unibertsitatea
    info

    Universidad del País Vasco/Euskal Herriko Unibertsitatea

    Lejona, España

    ROR https://ror.org/000xsnr85

Book:
Osasun zientziak: V. Ikergazte Nazioarteko Ikerteta Euskaraz. 2023eko maitzaren 17, 18 eta 19 Donostia, Euskal Herria.
  1. Olatz Arbelaitz Gallego (ed. lit.)
  2. Ainhoa Latatu (ed. lit.)
  3. Elixabete Pérez Gaztelu (ed. lit.)

Publisher: Udako Euskal Unibertsitatea, UEU = Universidad Vasca de Verano

ISBN: 978-84-8438-862-3,  978-84-8438-866-1

Year of publication: 2023

Pages: 159-166

Congress: Ikergazte. Nazioarteko Ikerketa Euskaraz (5. 2023. Donostia)

Type: Conference paper

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Abstract

Temporal lobe epilepsy is the most common type of epilepsy in adults. Although available anticonvulsants reduce the excessive neuronl excitability, they are not always effective. Nowadays research focuses on the control of neuroinflammatory mechanisms switched on in epilepsy. Hence, non-neuronal brain cells and the endocannabinoid system have emerged as potential targets because the role of this system in neuroiriflammation mediated by cannabinoid receptor-expressing glial cells. We show changes in glial cells and the cannabinoid 1 (CBI) receptor, the main target of endogenous and exogenous cannabinoids, throughout brain regions in a mouse model of temporal lobe epilepsy. Remarkably, these anatomical changes impact on cognition (memory) and behavioral states (anxiety).

Data source: Dialnet