Zelula barneko zein jariatutako CEMIPek larruazaleko fibroblastoen mugikortasuna erregulatzen du
- María Larrinaga Ruiz
- Andrea Agüera Lorente
- Ainhoa Alonso Pardavila
- María Dolores Boyano López
- Juan Manuel Falcón Pérez
- Aintzane Asumendi Mallea
- Aintzane Apraiz Garcia
- Olatz Arbelaitz Gallego (ed. lit.)
- Ainhoa Latatu (ed. lit.)
- Elixabete Pérez Gaztelu (ed. lit.)
Publisher: Udako Euskal Unibertsitatea, UEU = Universidad Vasca de Verano
ISBN: 978-84-8438-862-3, 978-84-8438-866-1
Year of publication: 2023
Pages: 145-152
Congress: Ikergazte. Nazioarteko Ikerketa Euskaraz (5. 2023. Donostia)
Type: Conference paper
Abstract
CEMIP is a protein with increased expression under chronic injlammation-involving conditions such as cancer, ofien linked to extracellular matrix remodeling and tumor progression. As shown in this work, motility of skin fibroblasts, key components of tumor microenvironment in cutaneous melanoma, was regulated by cellular CEMIP levels. Moreover, secreted CEMIP, both by fibroblasts and melanoma cells, was also able to modulate skinfibroblast migration