A direct route to Erythrinanes via α-amidoalkylation, conjugate addition and ring-closing metathesis reactions

  1. Osante, Inaki
  2. Sotomayor, Nuria
  3. Lete, Esther
Aldizkaria:
Letters in Organic Chemistry

ISSN: 1570-1786

Argitalpen urtea: 2004

Alea: 1

Zenbakia: 4

Orrialdeak: 323-325

Mota: Artikulua

DOI: 10.2174/1570178043400712 GOOGLE SCHOLAR lock_openSarbide irekia editor

Beste argitalpen batzuk: Letters in Organic Chemistry

Garapen Iraunkorreko Helburuak

Laburpena

A direct route to erythrinanes has been completed by a sequence that involves diastereoselective conjugate addition on a α,β-unsaturated lactam, followed by a ring-closing metathesis reaction to construct ring A. The synthesis of the key intermediates C-10b functionalized dihydropyrroloisoquinolines is achieved via Parham cyclisation and α-amidoalkylation reactions.