Role of sigma-1 receptor in central neuropathic pain development after mild spinal cord injury in mice
- Castany Quintana, Sílvia
- Pere Boadas Vaello Director
Universidade de defensa: Universitat de Girona
Fecha de defensa: 27 de outubro de 2017
- Josep Eladi Baños Díez Presidente/a
- Elisabeth Kádár García Secretario/a
- Nagore Puente Bustinza Vogal
Tipo: Tese
Resumo
Central neuropathic pain is present in in approximately 65% of spinal cord injured patients and, unfortunately, it is largely refractory to current treatments and has a poor recovery prognosis. It is therefore imperative to focus research efforts in identifying new therapeutic approaches. We assessed here the modulation of the sigma-1 receptor (σ1R), a chaperone protein that regulates nociceptive transmission processes. Thus, the global objective of the present thesis is to elucidate the role of σ1R in the modulation of SCI induced central neuropathic pain.