Role of sigma-1 receptor in central neuropathic pain development after mild spinal cord injury in mice

  1. Castany Quintana, Sílvia
Supervised by:
  1. Pere Boadas Vaello Director

Defence university: Universitat de Girona

Fecha de defensa: 27 October 2017

Committee:
  1. Josep Eladi Baños Díez Chair
  2. Elisabeth Kádár García Secretary
  3. Nagore Puente Bustinza Committee member

Type: Thesis

Teseo: 520203 DIALNET

Abstract

Central neuropathic pain is present in in approximately 65% of spinal cord injured patients and, unfortunately, it is largely refractory to current treatments and has a poor recovery prognosis. It is therefore imperative to focus research efforts in identifying new therapeutic approaches. We assessed here the modulation of the sigma-1 receptor (σ1R), a chaperone protein that regulates nociceptive transmission processes. Thus, the global objective of the present thesis is to elucidate the role of σ1R in the modulation of SCI induced central neuropathic pain.