Role of sigma-1 receptor in central neuropathic pain development after mild spinal cord injury in mice

Résumé

Central neuropathic pain is present in in approximately 65% of spinal cord injured patients and, unfortunately, it is largely refractory to current treatments and has a poor recovery prognosis. It is therefore imperative to focus research efforts in identifying new therapeutic approaches. We assessed here the modulation of the sigma-1 receptor (σ1R), a chaperone protein that regulates nociceptive transmission processes. Thus, the global objective of the present thesis is to elucidate the role of σ1R in the modulation of SCI induced central neuropathic pain.