Research and development of advanced controlled drug delivery systemsapplication in Keratoconus and Leber´s Hereditary Optic Neuropathy

  1. Varela Fernández, Rubén
Supervised by:
  1. Francisco Javier Otero Espinar Director
  2. Isabel Lema Gesto Director
  3. Miguel González Barcia Director

Defence university: Universidade de Santiago de Compostela

Fecha de defensa: 27 June 2022

Committee:
  1. José Blanco Méndez Chair
  2. Arantxa Acera Osa Secretary
  3. Alicia C. López Castellano Committee member

Type: Thesis

Teseo: 733876 DIALNET lock_openMINERVA editor

Abstract

In the present thesis, the research, development, and characterization processes of controlled drug delivery systems intended for the treatment of two different ocular pathologies were described. Firstly, different types of lactoferrin-loaded nanoparticles intended for topical ophthalmic administration were developed and proposed as the first pharmacological alternative for the Keratoconus (KC) treatment. On the other hand, idebenone-loaded polymeric implants and microparticles were designed and proposed as new therapeutic strategies for the treatment of Leber's Hereditary Optic Neuropathy (LHON).