La regulación epigenética en la línea germinal
ISSN: 1134-7198
Año de publicación: 2022
Número: 56
Páginas: 189-200
Tipo: Artículo
Otras publicaciones en: Revista de derecho y genoma humano: genética, biotecnología y medicina avanzada
Resumen
The manipulation of the genetic sequence of the germ line with current techniques generates great rejection due to the lack of specificity and safety, on the one hand, and, on the other hand, due to the direct action exerted on the sequence of bases of which the human genome is composed. Epigenetics offers us the possibility of acting on gene expression without altering the sequence, a plausible option that avoids certain bioethical confrontations. The knowledge that is being acquired in this field and its possible use in new therapeutic approaches opens up a new debate
Referencias bibliográficas
- ARNETH, Borros, “Tumor Microenvironment”, Medicina. Num. 30, Vol. 56, 2019.
- BALTIMORE, David / BERG, Paul / BOTCHAN, Michael, “A prudent path forward for genomic engineering and germ line gene modification”, Science, Num. 348, Vol. 6230, 2015.
- EUROPEAN GROUP ON ETHICS IN SCIENCE AND NEW TECHNOLOGIES ETHICS OF GENOME EDITING. Marzo 2021. GREELY, Henry T., “CRISPR’d babies: human germline genome editing in the ‘He Jiankui affair’”, J Law Biosci. Num.13, Vol. 6, 2019.
- GREGOR, Mary, “Groundwork of the metaphysics of morals, in Immanuel Kant”, Practical Philosophy, trans. New York: Cambridge University Press. 1996.
- HABERMAS, Jürgen, “The future of human nature”, Ed. Malden, Oxford, Reino Unido, 2003.
- JASANOFF, Sheila / HURLBUT, Benjamin / KRISHANU Saha, “Democratic Governance of Human Germline Genome”, The CRISPR Journal , Num. 5, Vol. 2, 2019
- JINEK, Martin / CHYLINSKI, Krzystof / FONFARA, Ines / HAUER, Michael / DOUDNA, Jennifer / CHARPENTIER, Emmanuelle, “A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity”, Science, Num. 337, Vol. 6096, 2012, pp. 816-21.
- LANDER, Erik, “The Heroes of CRISPR”, Cell, Num. 14, Vol. 2016.
- LEE, Rosalind / FEINBAUM, Ronda / AMBROS, Victor, “The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14”, Cell. Núm. 5, Vol. 75, 1993.
- MARQUEZ, Joana / FERNANDEZ-PIÑEIRO, Inés / ARAÚZO-BRAVO, Marcos Jesús / POSCHMANN, Gereon / STÜHLER, Kai / KHATIB, Abdel Majid / SANCHEZ, Alejandro / UNDA, Fernando / IBARRETXE, Gaskon / BERNALES, Irantzu / BADIOLA, Iker, “Targeting liver sinusoidal endothelial cells with miR-20a-loaded nanoparticles reduces murine colon cancer metastasis to the liver”, International Journal of Cancer. Núm. 1, Vol. 143, 2018.
- MIRANDA FURTADO, Cristiana Libardi / DOS SANTOS LUCIANO, María Claudia / SILVA SANTOS, Renan Da / FURTADO GILVAN, Pessoa / MORAES, Manuel Odorico / PESSOA, Claudia, “Epidrugs: targeting epigenetic marks in cancer treatment”, Epigenetics, Núm. 14, Vol. 12, 2019.
- NAKAMURA, Muneaki / GAO,Yuchen / DOMINGUEZ, Antonio / QI, Lei, “CRISPR technologies for precise epigenome editing”, Nat Cell Biol., Num. 23, Vol. 1, 2021.
- SANTALÓ-PEDRO, Josep, “Edición genómica. La hora de la reflexión / Gene editing. Time to reflection”, Rev. Bioética y Derecho, Num. 40, 2017.
- Declaración de la EASAC de 2017 sobre el uso de la edición genética Declaración de 2015 de la Cumbre Internacional sobre la Edición de Genes Humanos sobre la edición genética.
- Declaración del European Group on Ethics in Science and New Technologies de 2016.
- Declaración del Comité de Bioética de España sobre la edición genética en humanos del 18 de Enero de 2019.
- RAPOSO, Vera Lúcia, “Gene Editing, the Mystic Threat to Human Dignity”, Journal of Bioethical Inquiry, Vol.16, 2019.