Perfil de deterioro cognitivo en personas con esquizofrenia paranoide:Estudio breve en población peruana

  1. Jonathan A. Zegarra Valdivia 1
  2. Brenda Chino Vilca 1
  1. 1 Universidad Nacional de San Agustín de Arequipa, Perú
Journal:
Cuadernos de Neuropsicología

ISSN: 0718-4123

Year of publication: 2020

Volume: 14

Issue: 3

Pages: 121-129

Type: Article

DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Cuadernos de Neuropsicología

Abstract

Schizophrenia has an extensive burden of disease, social and functional alteration and a poor therapeutic response. These effects are related to significant disorders of the cognitive processes; however, they are often not properly evaluated or followed. The aim of this study was to know the applicability of the Addenbrooke's Cognitive Examination-Revised as an overall measure of the cognitive profile of patients with paranoid schizophrenia in mental health care. We compared the cognitive profile of subjects diagnosed with paranoid schizophrenia according to the DSM-IV-TR, to matched control subjects by age and sex, using a non-probabilistic and intentional sampling. Parametric (Student's T) and Non-Parametric (Mann Whitney U) statistics, as well as Linear Regression Analysis and Pearson's Correlation were performed. Statistically significant differences were found between the cognitive profiles of the clinical group and control.as well in different specific processes (Orientation, Memory, Verbal Fluency, Language, Visuospatial Ability). The item-test correlation was adequate, as well as the reliability obtained with Crombach's alpha (α = 0.885). Conclusion: ACE-R shows adequate reliability and its use for the assessment of cognitive processes in schizophrenia is very useful.

Bibliographic References

  • Aich, T. K., Mahato, A., & Subedi, S. (2017). Cognitive Impairment in Schizophrenia: Current Perspective. Journal of Psychiatrists’ Association of Nepal, 5(1), 5–13. https://doi.org/10.3126/jpan.v5i1.18324
  • Baier, B., Karnath, H.-O., Dieterich, M., Birklein, F., Heinze, C., & Müller, N. G. (2010). Keeping memory clear and stable--the contribution of human basal ganglia and prefrontal cortex to working memory. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 30(29), 9788–9792.
  • Bell, M., Fiszdon, J., Greig, T., Wexler, B., & Bryson, G. (2007). Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance. The Journal of Rehabilitation Research and Development, 44(5), 761.
  • Bell, M., Zito, W., Greig, T., & Wexler, B. E. (2008). Neurocognitive Enhancement Therapy and Competitive Employment in Schizophrenia: Effects on Clients with Poor Community Functioning. American Journal of Psychiatric Rehabilitation, 11(2), 109–122.
  • Brüne, M. (2005). “Theory of mind” in schizophrenia: A review of the literature. Schizophrenia Bulletin.
  • Cavieres F., A., & Valdebenito V., M. (2005). Funcionamiento cognitivo y calidad de vida en la esquizofrenia. Revista Chilena de NeuroPsiquiatría, 43(2), 97–108. https://doi.org/10.4067/S0717-92272005000200003
  • Fatemi, S. H. (2010). Clinical Handbook of Schizophrenia. The Journal of Clinical Psychiatry, 71(07), 962.
  • Fisekovic, S., Memic, A., & Pasalic, A. (2012). Correlation between MoCA and mmse for the assessment of cognition in schizophrenia. Acta Informatica Medica, 20(3), 186–189.
  • Gkintoni, E., Pallis, E. G., Bitsios, P., & Giakoumaki, S. G. (2017). Neurocognitive performance, psychopathology and social functioning in individuals at high risk for schizophrenia or psychotic bipolar disorder. Journal of Affective Disorders, 208(June 2016), 512–520.
  • Gliem, J. A., & Gliem, R. R. (2003). Calculating, Interpreting, and Reporting Cronbach’s Alpha Reliability Coefficient for Likert-Type Scales, (1992), 82–88. https://doi.org/10.1109/PROC.1975.9792
  • Green, M. F., Kern, R. S., & Heaton, R. K. (2004). Longitudinal studies of cognition and functional outcome in schizophrenia: Implications for
  • Hernández-Sampieri, R., Fernández-Collado, C., Baptista, L. (2010). Metodología de la Investigación.
  • Herrera-Pérez, E., Custodio, N., Lira, D., Montesinos, R., & Bendezu, L. (2013). Validity of Addenbrooke’s Cognitive Examination to Discriminate between Incipient Dementia and Depression in Elderly Patients of a Private Clinic in Lima, Peru. Dementia and Geriatric Cognitive Disorders Extra, 3(1), 333–341.
  • Kay, S. R., Fiszbein, A., & Opler, L. A. (1987). The Positive and Negative Syndrome Scale for schizophrenia. Schizophr Bull., 13(2), 261–276. https://doi.org/10.1093/schbul/13.2.261
  • Keefe, R. S. E. (2008). Should cognitive impairment be included in the diagnostic criteria for schizophrenia? World Psychiatry, 7(1), 22–28.
  • Kontis, D., Theochari, E., Andreopoulou, A., Vassilouli, S., Siettou, E., Kouloumbi, M., … Tsaltas, E. (2018). A Cognitive Rehabilitation Program for Psychoses : Origins , Development and Perspectives, 25– 37.
  • Liang, S., Deng, W., Wang, Q., Ma, X., Li, M., Brown, M. R. G., … Li, T. (2016). Performance of Verbal Fluency as an Endophenotype in Patients with Familial versus Sporadic Schizophrenia and Their Parents. Scientific Reports, 6(August), 1–10. https://doi.org/10.1038/srep32597
  • Matiás-Guiu, J. A., Valles-Salgado, M., Rognoni, T., Hamre-Gil, F., MorenoRamos, T., & Matiás-Guiu, J. (2017). Comparative Diagnostic Accuracy of the ACE-III, MIS, MMSE, MoCA, and RUDAS for Screening of Alzheimer Disease. Dementia and Geriatric Cognitive Disorders, 43(5– 6), 237–246. https://doi.org/10.1159/000469658
  • Montero, I., & León, O. G. (2007). A guide for naming research studies in Psychology. International Journal of Clinical and Health Psychology, 7(3), 847–862.
  • Müller, D. R., & Roder, V. (2010). Integrated psychological therapy and integrated neurocognitive therapy. In Neurocognition and Social Cognition in Schizophrenia Patients: Basic Concepts and Treatment (Vol. 177, pp. 118–144). https://doi.org/10.1159/000284383
  • Ojeda, N., Peña, J., Bengoetxea, E., García, A., Sánchez, P., Segarra, R., … Eguíluz, J. I. (2012). REHACOP: Programa de rehabilitación cognitiva en psicosis. Revista de Neurologia, 54(6), 337–342.
  • Penadés, R., Boget, T., Catalán, R., Bernardo, M., Gastó, C., & Salamero, M. (2003). Cognitive mechanisms, psychosocial functioning, and neurocognitive rehabilitation in schizophrenia. Schizophrenia Research, 63(3), 219–227. https://doi.org/10.1016/S0920-9964(02)00359-6
  • Rado, J., & Hernandez, E. (2014). Schizophrenia. Recent advances in diagnosis and treatment. (M. Janicak, P., Marder, S., Tandon, R., & Goldman, Ed.) (Springer). New York.
  • Robles, Y. (2003). Adaptacion del mini-mental state examination.
  • Rodríguez-Blanco, L., Lubrini, G., Vidal-Mariño, c., Ríos-Lago, M. (2017). Eficacia de la rehabilitación cognitiva de la atención, funciones ejecutivas y memoria operativa en los trastornos psicóticos. Revisión sistemática. Actas Esp Psiquiatr, 45(2), 167–178.
  • Russell, A. J., Munro, J. C., Jones, P. B., Hemsley, D. R., & Murray, R. M. (1997). Schizophrenia and the myth of intellectual decline. American Journal of Psychiatry, 154(5), 635–639. https://doi.org/10.1176/ajp.154.5.635
  • Schmidt, S. J., Mueller, D. R., & Roder, V. (2011). Social cognition as a mediator variable between neurocognition and functional outcome in schizophrenia: Empirical review and new results by structural equation modeling. Schizophrenia Bulletin. https://doi.org/10.1093/schbul/sbr079
  • Snitz, B. E., MacDonald, A. W., & Carter, C. S. (2006). Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: A metaanalytic review of putative endophenotypes. Schizophrenia Bulletin. https://doi.org/10.1093/schbul/sbi048
  • Stuchlik, A., & Sumiyoshi, T. (2014). Cognitive Deficits in Schizophrenia and Other Neuropsychiatric Disorders: Convergence of Preclinical and Clinical Evidence. Frontiers in Behavioral Neuroscience, 8. https://doi.org/10.3389/fnbeh.2014.00444
  • Tarlreja, B. T., Shah, S., & Kataria, L. (2013). Cognitive function in schizophrenia and its association with socio-demographics factors Cognitive function in schizophrenia and its association with sociodemographics factors : Bharti T Talreja , Sandeep Shah , Lakhan Kataria, I …. Industrial Psychiatry Journal, 22(1), 47–53.
  • Teresi, J. A. (2007). Mini-Mental State Examination (MMSE): Scaling the MMSE using item response theory (IRT). Journal of Clinical Epidemiology, 60(3), 256–259. https://doi.org/10.1016/j.jclinepi.2006.06.009
  • Til Wykes, Huddy, V., Cellard, C., McGurk, S., & Czobor, P. (2011). A MetaAnalysis of Cognitive Remediation for Schizophrenia: Methodology and Effect Sizes, (May), 472–485. https://doi.org/10.1176/appi.ajp.2010.10060855
  • Torralva, T., Roca, M., Gleichgerrcht, E., Bonifacio, A., Raimondi, C., & Manes, F. (2011). Validación de la versión en español del Addenbrooke’s Cognitive Examination-Revisado (ACE-R). Neurologia, 26(6), 351–356. https://doi.org/10.1016/j.nrl.2010.10.013
  • Xu, J. Q., Hui, C. L., Longenecker, J., Lee, E. H., Chang, W. C., Chan, S. K., & Chen, E. Y. (2014). Executive function as predictors of persistent thought disorder in first-episode schizophrenia: a one-year follow-up study. Schizophr Res, 159(2–3), 465–470. https://doi.org/10.1016/j.schres.2014.08.022
  • Yun, D. Y., Hwang, S. S. H., Kim, Y., Lee, Y. H., Kim, Y. S., & Jung, H. Y. (2011). Impairments in executive functioning in patients with remitted and non-remitted schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(4), 1148–1154. https://doi.org/10.1016/j.pnpbp.2011.03.018
  • Zegarra-Valdivia J, Cazorla E, & Chino-Vilca, B. (2016). Perfil clínico y epidemiológico de pacientes atendidos en el Centro de Salud Mental “ Moisés Heresi ” de Arequipa - Perú , entre los años 2011. Revista de Neuro-Psiquiatria, 79(2), 31–40.
  • Zegarra-Valdivia, J. A. (2015). Funcionamiento ejecutivo, teoría de la mente y toma de decisiones en pacientes estabilizados con esquizofrenia paranoide del sur del Perú. Revista Mexicana de Neurociencia, 16(3), 13–25.
Data source: Dialnet