Minbiziaren aurkako CAR-T zelulen bidezko immunoterapia

  1. Garcia Gallastegi, Patricia 1
  2. Mugica Basauri, Maite
  3. Crende Arruabarrena, Olatz
  1. 1 Universidad del País Vasco/Euskal Herriko Unibertsitatea
    info

    Universidad del País Vasco/Euskal Herriko Unibertsitatea

    Lejona, España

    ROR https://ror.org/000xsnr85

Journal:
Ekaia: Euskal Herriko Unibertsitateko zientzi eta teknologi aldizkaria

ISSN: 0214-9001

Year of publication: 2021

Issue: 40

Pages: 77-88

Type: Article

DOI: 10.1387/EKAIA.21946 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Ekaia: Euskal Herriko Unibertsitateko zientzi eta teknologi aldizkaria

Abstract

The last years immunotherapy has become a useful strategy in the fight against cancer. One of the most popular therapies is called CAR-T. In this treatment, the patient’s T lymphocytes are removed and modified in the laboratory to enhance the action against the tumour by placing a type of “sensor” on its surface (CAR receptor). Thus, the patient is re- introduced with the transformed lymphocytes, which search for, recognize, and attack tumour cells. In this review, we will explain the structure, mode of generation, and adverse effects of CAR receptors on therapy. Finally, CAR-T immunotherapy has been shown to be effective in several blood tumours, as well as in certain types of solid tumors.

Data source: Dialnet