Corneal regeneration after laser in-situ keratomileusiswound healing process and visual outcomes
- Ane Murueta-Goyena Larrañaga
- Javier Tomás-Juan
- Ludger Hanneken
ISSN: 2171-4703
Year of publication: 2015
Volume: 6
Issue: 4
Pages: 223-238
Type: Article
More publications in: Journal of Emmetropia: Journal of Cataract, Refractive and Corneal Surgery
Abstract
ABSTRACT: Laser in-situ keratomileusis (LASIK) is a widely performed refractive surgical procedure that provides excellent visual outcomes. Creation of the flap and stromal ablation disrupt corneal integrity and alter its function. Damaged epithelial cells release cytokines and growth factors that interact with stromal keratocytes to trigger the regeneration process. However, these interactions under the flap are limited, and stromal repair does not conclude. Keratocyte deficits and denervation are long-lasting following photoablation. Complications derived from biological variability in the wound healing response affect the predictability of LASIK surgery. Most of these complications can be prevented or effectively treated with minor impact on optical quality and few visual consequences.