Proteinen desnaturalizazio termalaren bidezko analisia konposatu bioeraginkor berriak aurkitzeko.
- Yuri Rueda Estevez
- Hiart Navarro Imaz
- Irati Rekondo
- Susana Cristobal
- Olatz Fresnedo Aranguren
ISSN: 0214-9001
Year of publication: 2020
Issue: 38
Pages: 231-240
Type: Article
More publications in: Ekaia: Euskal Herriko Unibertsitateko zientzi eta teknologi aldizkaria
Abstract
Bioactive compounds are either natural or synthetic chemicals that can affect both the cellular and/or physiological activity in living organisms. Included among these are, for example, drugs that can have beneficial effects on health, through the modulation of biological processes. The development of new strategies to search new bioactive compounds and their new biological targets is a high impact challenge. In order to find target proteins and mechanisms of action, several different methodologies have been developed, including the method discussed in this paper. It is based on the analysis of the modifications caused by bioactive compounds on the protein thermal denaturation process. This work describes the basics of this methodology suitable in the search of bioactive compounds as well as the criteria for its implementation.