Arming NK cells with chimeric antigen receptors (CARs) for treatment of refractory and/or relapsed hematological cancerspreclinical study to determine the best cell source

  1. HERRERA DEL VAL, LARA
Dirigida por:
  1. Cristina Eguizabal Argaiz Director/a
  2. Jon Arluzea de Jauregizar Director

Universidad de defensa: Universidad del País Vasco - Euskal Herriko Unibertsitatea

Fecha de defensa: 10 de febrero de 2020

Tribunal:
  1. Aintzane Asumendi Mallea Presidenta
  2. Manuel Juan Otero Secretario/a
  3. Unai Silván De Pedro Vocal

Tipo: Tesis

Teseo: 152035 DIALNET lock_openADDI editor

Resumen

Acute Lymphoblastic Leukemia (ALL) and Chronic Lymphocytic Leukemia (CLL) are the most prevalent hematological cancers in children and elder patients respectively. Sometimes, standard treatments are not enough for curing these patients and new approaches, like immunotherapy need to be explored. In the last years, Chimeric Antigen Receptors (CARs) have arisen as one of the most promising immunotherapies. Usually these CARs are used along with T cells, developing CAR-T cells. Although autologous CAR-T cells have given very good results, their secondary side effects, like cytokine storm and neurotoxicity, are quite severe; and the CAR-T product manufacturing takes 5 weeks minimum. Because of that, we suggest NK cells as a vehicle for allogeneic CAR based treatments, as they do not cause secondary side effects or graft versus host disease. In this thesis, we look for the best cell source inorder to obtain the perfect NK cells for CAR based treatments.