Intramolecular carbolithiation and palladium-catalyzed c-c bond forming reactions in the construction of medium sized rings. Selective synthesis of fused indolizine, pyrroloazepine and pyrroloazocine

Abstract

The research work described in this thesis has focused on the develop`ment of new methods for he syntehesis of heterocycles using organolithium intermediates and palladium-catalyzed coupling reactions for the formation of carbon-carbon bonds.the intramolecular carbolithiation reactionor arylithiums has been extended to the construction of medium sized rings, and has also been applied to heteroaryllilthiums. Besides, the competion between Mizoreoki-Heck and direct arylation reaction in the construction of medium sized rings on both aromatic and heteroaromatic systems has been studied. In this context, the asymmetric version of mizoroki-heck reactions, as well as cascade processes have also been studied. Thus. efficient procedures for the obtention of fused indlizine, pyrroloazepine and pyrroloazocine systems have been developed.