Publications (118) Publications de Arturo Muga Villate

2024

  1. A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion

    Journal of the American Chemical Society

  2. Author Correction: The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70 (Nature Communications, (2023), 14, 1, (5436), 10.1038/s41467-023-41150-8)

    Nature Communications

  3. Pseudophosphorylation of single residues of the J-domain of DNAJA2 regulates the holding/folding balance of the Hsc70 system

    Protein Science, Vol. 33, Núm. 8

2023

  1. The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70

    Nature communications, Vol. 14, Núm. 1, pp. 5436

2022

  1. Fine-tuning of the Hsc70-based Human Protein Disaggregase Machinery by the Distinctive C-terminal Extension of Apg2

    Journal of Molecular Biology, Vol. 434, Núm. 22

  2. Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, Núm. 41

2021

  1. All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Núm. 36

  2. Inhibition of the human hsc70 system by small ligands as a potential anticancer approach

    Cancers, Vol. 13, Núm. 12

  3. Truncation‐driven lateral association of α‐synuclein hinders amyloid clearance by the Hsp70‐based disaggregase

    International Journal of Molecular Sciences, Vol. 22, Núm. 23

  4. Unzipping the secrets of amyloid disassembly by the human disaggregase

    Cells, Vol. 10, Núm. 10

2020

  1. Extraction and Refolding Determinants of Chaperone-Driven Aggregated Protein Reactivation

    Journal of Molecular Biology, Vol. 432, Núm. 10, pp. 3239-3250

2019

  1. Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: Role of the Acidic Subdomain

    Journal of Molecular Biology, Vol. 431, Núm. 2, pp. 444-461

  2. Structural and functional insights on the roles of molecular chaperones in the mistargeting and aggregation phenotypes associated with primary hyperoxaluria type I

    Advances in Protein Chemistry and Structural Biology (Academic Press Inc.), pp. 119-152

  3. Structural insights into the ability of nucleoplasmin to assemble and chaperone histone octamers for DNA deposition

    Scientific Reports, Vol. 9, Núm. 1

  4. The complex phosphorylation patterns that regulate the activity of Hsp70 and its cochaperones

    International Journal of Molecular Sciences, Vol. 20, Núm. 17

2018

  1. Activation of the DnaK-ClpB Complex is Regulated by the Properties of the Bound Substrate

    Scientific Reports, Vol. 8, Núm. 1

2017

  1. Label-Free, Multiplexed, Single-Molecule Analysis of Protein-DNA Complexes with Nanopores

    ACS Nano, Vol. 11, Núm. 6, pp. 5815-5825

2016

  1. A Quantitative Characterization of Nucleoplasmin/Histone Complexes Reveals Chaperone Versatility

    Scientific Reports, Vol. 6

  2. Crowding Modulates the Conformation, Affinity, and Activity of the Components of the Bacterial Disaggregase Machinery

    Journal of Molecular Biology, Vol. 428, Núm. 11, pp. 2474-2487

2015

  1. Chaperone-assisted protein aggregate reactivation: Different solutions for the same problem

    Archives of Biochemistry and Biophysics, Vol. 580, pp. 121-134