Structural Biology of Disease Mechanisms Laboratory
Universidad del País Vasco/Euskal Herriko Unibertsitatea
Lejona, EspañaPublikationen in Zusammenarbeit mit Forschern von Universidad del País Vasco/Euskal Herriko Unibertsitatea (15)
2024
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Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis
Nature Structural and Molecular Biology, Vol. 31, Núm. 9, pp. 1394-1403
2023
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Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane
Nature Communications, Vol. 14, Núm. 1
2021
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Conformational plasticity underlies membrane fusion induced by an HIV sequence juxtaposed to the lipid envelope
Scientific Reports, Vol. 11, Núm. 1
2020
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Presenilin1 familial Alzheimer disease mutants inactivate EFNB1-and BDNF-dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of N-methyl-d-Aspartate receptor
Brain Communications, Vol. 2, Núm. 2
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Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin
Nature Communications, Vol. 11, Núm. 1
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Structural insight into the membrane targeting domain of the Legionella deAMPylase SidD
PLoS Pathogens, Vol. 16, Núm. 8
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Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis
Nature Structural and Molecular Biology, Vol. 27, Núm. 10, pp. 913-924
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Substrate interaction inhibits γ-secretase production of amyloid-β peptides
Chemical Communications, Vol. 56, Núm. 17, pp. 2578-2581
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Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype
Frontiers in Molecular Neuroscience, Vol. 13
2019
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Vitamin B 12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection
Cell Research, Vol. 29, Núm. 4, pp. 313-329
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CD46 facilitates entry and dissemination of human cytomegalovirus
Nature Communications, Vol. 10, Núm. 1
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Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme
Nature Structural and Molecular Biology, Vol. 26, Núm. 10, pp. 955-962
2018
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Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloid Precursor Protein
Scientific Reports, Vol. 8, Núm. 1
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Design and validation of an open-source modular Microplate Photoirradiation System for high-Throughput photobiology experiments
PLoS ONE, Vol. 13, Núm. 10
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Unwinding of the Substrate Transmembrane Helix in Intramembrane Proteolysis
Biophysical Journal, Vol. 114, Núm. 7, pp. 1579-1589