Publications en collaboration avec des chercheurs de Icahn School of Medicine at Mount Sinai (28)

2024

  1. Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis

    Nature Structural and Molecular Biology, Vol. 31, Núm. 9, pp. 1394-1403

2022

  1. Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch

    Nature Communications, Vol. 13, Núm. 1

2020

  1. Presenilin1 familial Alzheimer disease mutants inactivate EFNB1-and BDNF-dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of N-methyl-d-Aspartate receptor

    Brain Communications, Vol. 2, Núm. 2

  2. Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin

    Nature Communications, Vol. 11, Núm. 1

  3. Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis

    Nature Structural and Molecular Biology, Vol. 27, Núm. 10, pp. 913-924

  4. Substrate interaction inhibits γ-secretase production of amyloid-β peptides

    Chemical Communications, Vol. 56, Núm. 17, pp. 2578-2581

2019

  1. Vitamin B 12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection

    Cell Research, Vol. 29, Núm. 4, pp. 313-329

  2. CD46 facilitates entry and dissemination of human cytomegalovirus

    Nature Communications, Vol. 10, Núm. 1

  3. Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme

    Nature Structural and Molecular Biology, Vol. 26, Núm. 10, pp. 955-962

2018

  1. Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloid Precursor Protein

    Scientific Reports, Vol. 8, Núm. 1

  2. Design and validation of an open-source modular Microplate Photoirradiation System for high-Throughput photobiology experiments

    PLoS ONE, Vol. 13, Núm. 10

  3. Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease

    Science Translational Medicine, Vol. 10, Núm. 423

  4. Unwinding of the Substrate Transmembrane Helix in Intramembrane Proteolysis

    Biophysical Journal, Vol. 114, Núm. 7, pp. 1579-1589

2017

  1. A New Method to Determine the Transmembrane Conformation of Substrates in Intramembrane Proteolysis by Deep-UV Resonance Raman Spectroscopy

    Methods in Enzymology (Academic Press Inc.), pp. 207-228

2016

  1. Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Núm. 30, pp. E4357-E4366

2015

  1. Sparse and incomplete factorial matrices to screen membrane protein 2D crystallization

    Journal of Structural Biology, Vol. 189, Núm. 2, pp. 123-134

2013

  1. Inward-facing conformation of the zinc transporter YiiP revealed by cryoelectron microscopy

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Núm. 6, pp. 2140-2145

  2. The Architecture of Yeast DNA Polymerase ζ

    Cell Reports, Vol. 5, Núm. 1, pp. 79-86

2012

  1. Membrane protein structure determination by electron crystallography

    Current Opinion in Structural Biology, Vol. 22, Núm. 4, pp. 520-528

2011

  1. Molecular determinants and thermodynamics of the amyloid precursor protein transmembrane domain implicated in alzheimer's disease

    Journal of Molecular Biology, Vol. 408, Núm. 5, pp. 879-895