Laboratory of Humanized Models of Disease
Publicacións (22) Publicacións nas que participase algún/ha investigador/a
2024
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Centenarian hippocampus displays high levels of astrocytic metallothioneins
Aging Cell, Vol. 23, Núm. 8
2023
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A neuron-specific interaction between Alzheimer's disease risk factors SORL1, APOE, and CLU
Cell Reports
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MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease
Science (New York, N.Y.), Vol. 381, Núm. 6663, pp. 1176-1182
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hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer’s disease and potential therapeutics
Molecular Neurodegeneration
2022
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Evolution of neuroglia
Annals of the New York Academy of Sciences, Vol. 1518, Núm. 1, pp. 120-130
2021
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Astrocytes in Alzheimer's Disease: Pathological Significance and Molecular Pathways
Cells, Vol. 10, Núm. 3
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Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques
Molecular Neurodegeneration, Vol. 16, Núm. 1
2019
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PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome
Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Núm. 1, pp. 277-286
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Stem-cell-derived human microglia transplanted in mouse brain to study human disease
Nature Neuroscience, Vol. 22, Núm. 12, pp. 2111-2116
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The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications
The Lancet Neurology, Vol. 18, Núm. 4, pp. 406-414
2017
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Brain extracellular space, hyaluronan, and the prevention of epileptic seizures
Reviews in the Neurosciences, Vol. 28, Núm. 8, pp. 869-892
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Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity (PLoS ONE) (2017) 12:2 (e0171968) DOI: 10.1371/journal.pone.0171968)
PLoS ONE
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Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
Neuron, Vol. 93, Núm. 5, pp. 1066-1081.e8
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PLD3 gene and processing of APP
Nature
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Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity
PLoS ONE, Vol. 12, Núm. 2
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Tetraspanin 6: A pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments
Molecular Neurodegeneration, Vol. 12, Núm. 1
2015
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LRRK2 functions in synaptic vesicle endocytosis through a kinasedependent mechanism
Journal of Cell Science, Vol. 128, Núm. 3, pp. 541-552
2014
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Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space
Journal of Neuroscience, Vol. 34, Núm. 18, pp. 6164-6176
2010
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Increased expression of glutamate transporters in subcortical white matter after transient focal cerebral ischemia
Neurobiology of Disease, Vol. 37, Núm. 1, pp. 156-165
2008
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Functional glutamate transport in rodent optic nerve axons and glia
GLIA, Vol. 56, Núm. 12, pp. 1353-1367