Pharmacokinetics and metabolomics in paediatric studies
- BLANCO ARANA, MARIA ENCARNACION
- Oskar Gonzalez Mendia Director
- Rosa Maria Alonso Rojas Director
Universidade de defensa: Universidad del País Vasco - Euskal Herriko Unibertsitatea
Fecha de defensa: 14 de marzo de 2016
- Nestor Etxebarria Loizate Presidente
- Antonia García Fernández Secretario/a
- Giuseppe Giordano Vogal
Tipo: Tese
Resumo
One of the main problems encountered in clinical pharmacology is the lack of information available for pharmaceutical drugs in paediatric population. As a result, many drugs are used off-label, and the doses are adjusted using empirical algorithms from allometric models optimised for adults. However, this does not take into consideration the different grades of maturation of the organs involved in the absorption, distribution, metabolism and elimination (ADME) processes of drugs in children. To address this problematic two approaches are presented in this thesis: the evaluation of pharmacokinetic predictive models in paediatric population and the use of metabolomics as an innovative tool to differentiate the grades of maturation in paediatrics.