Funcionamiento premórbido en los trastornos psicóticos de inicio temprano: diferencias entre personas diagnosticadas de esquizofrenia, trastorno bipolar y población sana

Resumo

Background: Despite the large body of research on premorbid impairments in schizophrenia, studies comparing different early-onset psychoses (EOS) are scarce. Aims: To examine premorbid impairments in first episodes of early-onset schizophrenia (SZ) and bipolar disorder (BD) Method: We compared premorbid adjustment and other premorbid variables in a cohort of children and adolescents with SZ and BD experiencing their first psychotic episode and in a healthy control group. Results: EOS showed lower intellectual ability and worse global and academic premorbid adjustment in childhood and early adolescence. SZ showed more social impairment in childhood than BD and healthy controls and had higher rates of developmental abnormalities than healthy controls. BD had higher rates of previous psychiatric diagnosis, especially of mood and anxiety disorders .Between childhood and early adolescence, SZ and BD showed a greater decline in academic adjustment than healthy controls, more specifically in adaptation to school. No significant differences between EOS and controls were found in obstetric complications. Conclusions: EOS had more premorbid impairment and higher rates of premorbid abnormalities than healthy controls. SZ shows more early social impairment than early-onset BD meanwhile early -onset BD had higer rates of life time anxiety and mood disorders .Intellectual premorbid abnormalities are less specific and probably more linked to early-onset psychosis. The association between early onset psychosis and obstetric complications need further studies with larger samples.