Aplicaciones biomédicas de nanogeles dendríticos termosensibles
- Maria Molina 1
- Julian Bergueiro 1
- Ana Sousa-Hervés 1
- Marcelo Calderón 1
- 1 Freie Universität Berlin
ISSN: 0121-6651, 1988-4206
Année de publication: 2015
Volumen: 16
Número: 3
Pages: 164-172
Type: Article
D'autres publications dans: Revista Iberoamericana de Polímeros
Résumé
Nanogels are nanosized crosslinked networks composed of hydrophilic or amphiphilic polymer chains that are capable of absorbing and releasing large quantities of water. They are developed as carriers to transport drugs or biomacromolecules. Thermoresponsive polymers undergo a phase transition at a certain temperature in aqueous media known as phase transition (Tp). As a consequence, they can change their aggregation state, exhibit conformational change and undergo shrinking, swelling, or micellization upon a thermal trigger. The combination of the nanogel properties and thermo-responsiveness represents a promising approach for the development of stimuli-controlled release systems, which reveals high loading capacity and improves the in vivo drug stability. Herein, the engineering of thermoresponsive dendritic nanogels (dNGs) using different thermoresponsive linear polymers and dendritic polyglycerol as macro-crosslinker for biomedical applications is reviewed.